Not ready for filler or fat grafting, but your neck or jawline bothers you? Here is what a 5% volufiline cream can and cannot do.
Short answer:
- Scared of filler or fat grafting? This is a low-risk, affordable thing to try first.
- The label is clean: no fragrance, essential oils or ethanol. It works as a neck moisturiser.
- It will not do what a clinic can. The volume claim rests on the supplier’s own small test, and a cream is not a filler.
What is volufiline?
Volufiline is a trade name owned by Sederma, a French ingredient supplier. It is sarsasapogenin from the root of an Asian herb, Anemarrhena asphodeloides, dissolved in an oil [1].
On a label, look for hydrogenated polyisobutene (the oil) and Anemarrhena asphodeloides root extract [1]. The supplier says it helps skin cells store more fat [1].
Why is it expensive?
Volufiline creams often cost more than plain moisturisers because the ingredient is a trademarked name. Its price to brands is not public. This one sits at the friendly end of the range.
- Same 5%, much lower price. On each brand’s official store on 13 October 2026, medicube’s neck cream was $32 for 90 g. Then I Met You’s snail mucin eye cream, also labelled 5% volufiline, was $46 for 15 mL. Per gram, medicube’s costs about one-eighth as much.
- More money does not mean more volufiline. The supplier suggests 5% [1], and both creams say 5%.
So if you want to try volufiline, this is a fair-priced way to do it.
Does it work?
Here is the evidence, in one place.
- The supplier’s human test [1]: 30 women aged 18 to 35 put a 5% gel-cream on one breast, twice a day for 56 days. The treated side grew 2.2% on average and the untreated side 0.9%. The supplier’s p value was 0.1, so chance cannot be ruled out. The “up to 8.4%” in ads is the quarter of women who changed most. No face or neck was tested.
- How much is in the cream: most of the 5% is oil. My rough estimate from the supplier’s figure is about 0.002% of the plant compound in the finished cream [1].
- Outside research: I found no independent study of volufiline on human skin; the one paper I found only names it [2].
- medicube’s own test reports a slimmer jawline after one use. That is too soon for fat cells to change, so I read it as the gua sha massage easing puffiness for a while (clinical judgement).
What it can do: keep neck skin moist and smooth, with a massage tool built in. What it cannot do: fill a hollow. A cream is not a filler. Filler is a gel placed under the skin; a cream stays on top. I compare fillers in Neuramis vs Juvederm vs YVOIRE.
What else is in this cream?
- Moisture and slip: glycerin (2nd), hyaluronic acid and silicones that help the gua sha glide.
- Niacinamide (5th): supports the skin barrier; a few people get redness or stinging.
- Wrinkle helpers: adenosine, sodium DNA (PDRN), a little retinol, peptides, ceramide.
- Not listed: fragrance, essential oils, ethanol, exfoliating acids.
Not ready for filler, but your neck bothers you?
Dry neck skin, fine lines, a jawline you wish looked firmer → medicube PDRN Collagen Gua Sha Neck Wrinkle Cream.
- My view: try this first. If you still want more after two or three months, that is the time to talk to a clinic.
- My caution: it is rich, so keep it off acne-prone faces, and the retinol and niacinamide may sting a sensitive neck.
Photo: the brand’s official site.
Photo: the brand’s official site.
What I tell my patients
- Start with the cream. Use it daily, glide the gua sha lightly, and skip red or broken skin. Try it under the jaw for a few days first.
- Give it two or three months. Expect softer, smoother skin, not new volume.
- If you still want volume, that is a clinic treatment. Hyaluronic acid filler slowly breaks down over months, so it needs top-ups, and it has its own risks such as bruising and swelling.
- Pregnant or planning to be? Ask your own doctor about retinol.
- Just had filler or a skin booster? Read what to put on afterwards.
Fine to use means the label is fine. The main claim has no independent evidence yet.
Read next
- Why Do Koreans Put Eye Cream on Their Whole Face?
- Neuramis vs Juvederm vs YVOIRE: Are Korean Fillers as Good?
FAQ
Does volufiline really work?
As a neck moisturiser, yes. For volume, the only human data come from the supplier’s small test on breasts, where the change was small and could have been chance. Treat it as a gentle first step, not a replacement for a clinic treatment.
Is a volufiline cream the same as filler?
No. Filler is a gel placed under the skin, where it fills the spot it is put in. A cream sits on the skin’s surface, and no study I found shows it filling a face the way filler does.
Is volufiline made from sesame?
No. The supplier’s data sheet says it is sarsasapogenin from the root of Anemarrhena asphodeloides, an Asian herb, dissolved in an oil.
As an Amazon Associate I earn from qualifying purchases. This article contains affiliate links: if you buy through them, I may earn a small commission at no extra cost to you. It does not change what I recommend.
References
- Sederma (Croda). VOLUFILINE™ product data and claim substantiation: in vitro 3T3-L1 cells; in vivo 30 women, 56 days, FOITS. Supplier data, not a peer-reviewed study. Distributor copy of Sederma data sheet: soap-formula.ru
- Kim HM, Kang YM, Jin BR, Lee M, An HJ. Anti-inflammatory capacity of a medicinal herb extract, Anemarrhena asphodeloides, on in vivo and in vitro models-induced atopic dermatitis. Heliyon 2024;10(19):e37935. doi:10.1016/j.heliyon.2024.e37935
Disclaimer: I write about cosmetics and shops based on clinical experience. Product mentions reflect my clinical opinion; availability and formulas change, so check the current label. Skin responds differently from person to person, so patch test anything new, and see a doctor about a skin condition.
14 years in practice · replies to messages herselfA doctor in Korea, in practice since 2012 — your K-Beauty Doc. Physician in non-surgical aesthetic medicine, practising in Ansan, South Korea. Every article here is written from clinical practice and the published literature. Not medical advice.
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